Ausgewählte Publikationen Mykobakteriologie und NZM
Switching residues: A platform for the synthesis of Fidaxomin antibiotics.
Jung E, Griesser T, Costafrolaz J, Duverger O, Mattenberger Y, Dittmann S, Dorst A, Major A, Dailler D, Schäfle D, Sievers S, Brodolin K, Viollier PH, Sander P, Gademann K (2024)
Angewandte Chemie Int Ed: in press
Durlobactam boosts the clinical utility of standard of care β-lactams against Mycobacterium abscessus lung disease.
Negatu DA, Aragaw W, Gebresilase TT, Shin SJ, Sander P, Dartois V, Dick T, Paruchuri S, Kaya F (2024) Antimicrob Agents Chemother: in press
Clinical and genomic features of Mycobacterium avium complex: a multi-national European study.
Wetzstein N, Diricks M, Anton TB, Andres S, Kuhns M, Kohl TA, Schwarz C, Lewin A, Kehrmann J, Kahl BC, Schmidt A, Zimmermann S, Jansson MK, Baron SA, Schulthess B, Hogardt M, Friesen I, Niemann S, Wichelhaus TA (2024) Genome Med 16: 86
Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins.
Dharuman S, Phelps GA, Dunn CM, Wilt LA, Murphy PA, Lee RB, Snoke HE, Selchow P, Haldimann K, Böttger EC, Hobbie SN, Sander P, Lee RE. J Antibiot (Tokyo): Online ahead of print
Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus.
Phelps GA, Cheramie MN, Fernando DM, Selchow P, Meyer CJ, Waidyarachchi SL, Dharuman S, Liu J, Meuli M, Molin MD, Killam BY, Murphy PA, Reeve SM, Wilt LA, Anderson SM, Yang L, Lee RB, Temrikar ZH, Lukka PB, Meibohm B, Polikanov YS, Hobbie SN, Böttger EC, Sander P, Lee RE (2024) Proc Natl Acad Sci 121: e2314101120
Phenolic Substitution in Fidaxomicin: A Semisynthetic Approach to Antibiotic Activity Across Species.
Jung E, Kraimps A, Dittmann S, Griesser T, Costafrolaz J, Mattenberger Y, Jurt S, Viollier PH, Sander P, Sievers S, Gademann K (2023) Chembiochem: Online ahead of print
Longitudinal increase in the detection rate of Mycobacterium chimaera in heater-cooler device-derived water samples.
Schreiber PW, Zihlmann R, Schärer V, Hasse B, Imkamp F, Schulthess B, Sander P, Zingg W (2023) J Hosp Infect 131: 190-193
The aminoglycoside modifying enzyme Eis2 represents a new potential in vivo target for reducing antimicrobial drug resistance in Mycobacterium abscessus complex.
Lorè NI, Saliu F, Spitaleri A, Schäfle D, Nicola F, Cirillo DM, Sander P (2022) Eur Respir J 60: 2201541
The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysis.
Walker TM, Miotto P, Köser CU, Fowler PW, Knaggs J, Iqbal Z, Hunt M, Chindelevitch L, Farhat M, Cirillo DM, Comas I, Posey J, Omar SV, Peto TEA, Suresh A, Uplekar S, Laurent S, Colman RE, Nathanson CM, Zignol M, Walker AS, Crook DW, Ismail N, Rodwell TC, CRyPTIC Consortium, Seq&Treat Consortium (Böttger EC) (2022) Lancet Microbe 3: e265-e273
Consensus management recommendations for non-tuberculous mycobacterial pulmonary diseases.
Lange C, Böttger EC, Cambau E, Griffith DE, Guglielmetti L, van Ingen J, Knight SL, Marras TK, Oliver KN, Santin M, Stout JE, Tortoli E, Wagner D, Winthrop K, Daley CL, on behalf of the expert panel group for management recommendations in NTM-PD (2022) Lancet Infect Dis 22: e178-e190
Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment. Antimycobacterial Susceptibility Testing Group (2022) Eur Respir J 59: 166-166
Bedaquiline and clofazimine MIC of Mycobacterium abscessus depends on medium and incubation time. Schulthess B, Aktoğan Kittana FN, Hömke R, Sander P (2022) Antimicrob Agents Chemother 66: e0234621
Apramycin overcomes the inherent lack of antimicrobial bactericidal activity in Mycobacterium abscessus. Selchow P, Ordway DJ, Verma D, Whittel N, Petrig A, Hobbie SN, Böttger EC, Sander P (2022) Antimicrob Agents Chemother 66: e0151021
Aquimarins, peptide antibiotics with amino-modified C-termini from a sponge-derived Aquimarina sp. bacterium.
Dieterich CL, Probst SI, Ueoka R, Sandu I, Schäfle D, Dal Molin M, Minas HA, Costa R, Oxenius A, Sander P, Piel J (2022) Angew Chem Int Ed Engl 61: e202115802
Photochemically-mediated inflammation and cross-presentation of Mycobacterium bovis BCG proteins stimulates strong CD4 and CD8 T-cell responses in mice.
Waeckerle-Men Y, Kotkowska ZK, Bono G, Duda A, Kolm I, Varypataki EM, Amstutz B, Meuli M, Høgset A, Kündig TM, Halin C,Sander P, Johansen P (2022) Front Immunol 13: 815609
Drug susceptibility distributions of Mycobacterium chimaera and other non-tuberculous mycobacteria. Schulthess B, Schäfle D, Kälin N, Widmer T, Sander P (2021) Antimicrob Agents Chemother 65: e02131-20
Rifabutin is inactivated by Mycobacterium abscessus Arr. Schäfle D, Selchow P, Borer B, Meuli M, Rominski A, Schulthess B, Sander P (2021) Antimicrob Agents Chemother 65: e02215-20
Novel fidaxomicin antibiotics through site-selective catalysis.
Dailler D, Dorst A, Schäfle D, Sander P, Gademann K (2021) Commun Chem 4: 59
Phylogenomics of Mycobacterium africanum reveals a new lineage and a complex evolutionary history.
Coscolla M, Brites D, Menardo F, Loiseau C, Borrell S, Otchere ID, Asante-Poku A, Asare P, Sanchez-Buso L, Gehre F, N'Dira Sanoussi C, Antonio M, Dissou A, Ruiz-Rodriguez P, Fyfe J, Becket P, Niemann S, Alabi AS, Grobusch MP, Kobbe R, Parkhill J, Beisel C, Fenner L, Böttger EC, Meehan CJ, Harris SR, De Jong BC, Yeboah-Manu D, Gagneux S (2021) Microb Genom 7: 000477
Mycobacterium helveticum sp. nov., a novel slowly growing mycobacterial species associated with granulomatous lesions in adult swine.
Ghielmetti G, Rosato G, Trovato A, Friedel U, Kirchgaessner C, Perroulaz C, Pendl W, Figi R, Schulthess B, Bloemberg GV, Keller PM, Stephan R, Tortoli E (2021) Int J Syst Evol Microbiol 71: 004615
Mortality from drug-resistant tuberculosis in high-burden countries comparing routine drug susceptibility testing with whole-genome sequencing: a multicentre cohort study.
Züricher K, Reichmuth ML, Ballif M, Loiseau C, Borrell S, Reinhard M, Skrivankova V, Hömke R, Sander P, Avihingsanon A, Abimiku AG, Marcy O, Collantes J, Carter EJ, Wilkinson RJ, Cox H, Yotebieng M, Huebner R, Fenner L, Böttger EC, Gagneux S, Egger M, on behalf of IeDEA (2021) Lancet Microbe 2: e320-330
Mycobacterium tuberculosis phosphoribosyltransferase promotes bacterial survival in macrophages by inducing histone hypermethylation in autophagy-regulated genes.
Sengupta S, Nayak B, Meuli M, Sander P, Mishra S, Sonawane A (2021) Front Cell Infect Microbiol 11: 676456
Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline.
Daley CL, Iccarino JM, Lange C, Cambau E, Wallace Jr. RJ, Andrejak C, Böttger EC, Brozek J, Griffith DE, Guglielmetti L, Huitt GA, Knight SL, Leitman P, Marras TK, Oliver KN, Santin M, Stout JE, Tortoli E, van Ingen J, Wagner D, Winthrop KL (2020) Eur Respir J 56: 2000535
KatG as counterselection marker for nontuberculous mycobacteria. Gagliardi A, Selchow P, Luthra S, Schäfle D, Schulthess B, Sander P (2020) Antimicrob Agents Chemother 64: e02508-19
HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis.
Loiseau C, Brites D, Reinhard M, Zürcher K, Borrell S, Ballif M, Fenner L, Cox H, Rutaihwa LK, Wilkinson RJ, Yotebieng M, Carter EJ, Abimiku A, Marcy, Gotuzzo OE, Avihingsanon A, Zetola N, Doulla B, Böttger EC, Egger M, Gagneux S (2020) Antimicrob Agents Chemother 64: e00782-20
Diversity of nontuberculous mycobacteria in Heater-Cooler Devices - results from prospective surveillance.
Kaelin MB, Kuster SP, Hasse B, Schulthess B, Imkamp F, Halbe M, Sander P, Sax H, Schreiber PW (2020) J Hosp Infect 105: 480-485
International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass.
Hasse B, Hannan M, Keller PM, Maurer FP, Sommerstein R, Mertz D, Wagner D, Fernández-Hidalgo N, Nomura J, Manfrin V, Bettex D, Conte AH, Durante-Mangoni E, Hing-Cheung Tang T, Stuart RL, Lundgren J, Gordon S, Jarashow MC, Schreiber PW, Niemann S, Kohl TA, Daley C, Stewardson AJ, Whitener CJ, Perkins K, Plachouras D, Lamagni T, Chand M, Freiberger T, Zweifel S, Sander P, Schulthess B, Scriven J, Sax H, van Ingen J, Mestres CA, Diekema D, Brown-Elliott BA, Wallace RJ Jr, Baddour LM, Miro JM, Hoen B; M. chimaera ISCVID investigators; Infectious Diseases specialists; Hospital epidemiologists; Microbiologists and molecular typing specialists; Cardiac surgeons/ perfusionists/ cardiologists; Ophthalmology; Anaesthesiologists; Public Health (2020) J Hosp Infect 104: 214-235
Identification of novel scaffolds targeting Mycobacterium tuberculosis. Dal Molin M,Selchow P, Schäfle D, Tschumi A, Ryckmans T, Laage-Witt S, Sander P (2019) J Mol Med 97:1601-1613
Whole genome sequencing for drug resistance profile prediction in Mycobacterium tuberculosis.
Gygli S, Keller P, Ballif M, Blöchliger N, Hömke R, Reinhard M, Loiseau C, Ritter C, Sander P, Borrell S, Collantes J, Avihingsanon A, Gnokoro J, Yotebieng M, Egger M, Gagneux S, Böttger EC (2019) Antimicrob Agents Chemother 63: e02175-18
Drug susceptibility testing and mortality in patients treated for tuberculosis in high-burden countries: a multi-centre cohort study.
Zürcher K, Ballif M, Fenner L, Borrell S, Keller PM, Gnokoro J, Marcy O, Yotebieng M, Diero L, Carter EJ, Rockwood N, Wilkinson RJ, Cox H, Ezati N, Abimiku AG, Collantes J, Avihingsanon A, Kawkitinarong K, Reinhard M, Hömke R, Huebner R, Gagneux S, Böttger EC, Egger M (2019) Lancet Infect Dis 19: 298-307
Increased drug permeability of a stiffened mycobacterial outer membrane in cells lacking MFS transporter Rv1410 and lipoprotein LprG.
Hohl M, Remm S, Eskandarian HA, Dal Molin M, Arnold FM, Hürlimann LM, Krügel A, Fantner GE, Sander P, Seeger MA(2019) Mol Microbiol 111: 1263-1282
Discovery and characterization of Mycobacterium basiliense sp nov, a nontuberculous mycobacterium isolated from human lungs.
Seth-Smith HM, Imkamp F, Tagini F, Cuenod A, Hoemke R, Tschacher JK, Grendelmeier P, Baettig V, Erb S, Reinhard M, Ruettimann G, Borrell S, Gagneux S, Casanova C, Droz S, Osthoff M, Tamm M, Nübel U, Greub G, Keller PM, Egli A (2019) Frontiers in Microbiolgy 9: 3184
A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study.
Walker TM, Merker M, Knoblauch AM, Helbling P, Schoch OD, van der Werf MJ, Kranzer K, Fiebig L, Kröger S, Haas W, Hoffmann H, Indra A, Egli A, Cirillo DM, Robert J, Rogers TR, Groenheit R, Mengshoel AT, Mathys V, Haanperä M, Soolingen DV, Niemann S, Böttger EC, Keller PM; MDR-TB Cluster Consortium (2018) Lancet Infect Dis 18: 431-440
Treatment outcome definitions in nontuberculous mycobacterial pulmonary disease: an NTM-NET consensus statement.
van Ingen J, Aksamit T, Andrejak C, Böttger EC, Cambau E, Daley CL, Griffith DE, Guglielmetti L, Holland SM, Huitt GA, Koh WJ, Lange C, Leitman P, Marras TK, Morimoto K, Olivier KN, Santin M, Stout JE, Thomson R, Tortoli E, Wallace RJ Jr, Winthrop KL, Wagner D; for NTM-NET (2018) Eur Respir J 51: 1800170
The role of antibiotic-target-modifying and antibiotic-modifying enzymes in Mycobacterium abscessus drug resistance. Luthra S, Rominski A, Sander P (2018) Front Microbiol 9: 2179
Molecular mechanisms of intrinsic streptomycin resistance in Mycobacterium abscessus. Dal Molin M, Gut M, Rominski A, Haldimann K, Becker K, Sander P (2018) Antimicrob Agents Chemother 62: e01427-17
Global outbreak of severe Mycobacterium chimaera disease after cardiac surgery: a molecular epidemiological study.
van Ingen J, Kohl TA, Kranzer K, Hasse B, Keller P, Szafrańska AK, Hillemann D, Chand M, Schreiber PW, Sommerstein R, Berger C, Genoni M, Rüegg C, Troillet N, Widmer AF, Becker SL, Herrmann M, Eckmanns T, Haller S, Höller C, Debast SB, Wolfhagen MJ, Hopman J, Kluytmans J, Langelaar M, Notermans DW, ten Oever J, van den Barselaar P, Vonk AB, Vos MC, Ahmed N, Brown T, Crook D, Lamagni T, Phin N, Smith G, Zambon M, Serr A, Götting T, Ebner W, Thürmer A, Utpatel C, Spröer C, Bunk B, Nübel U, Bloemberg GV, Böttger EC, Niemann S, Wagner D, Sax H (2017) Lancet Infect Dis 17: 1033-1041
Development of a novel lead that targets M. tuberculosis polyketide synthase 13.
Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, Riley J, Epemolu O, Norval S, Snavely T, Robertson GT, Rubin EJ, Ioerger TR, Sirgel FA, van der Merwe R, van Helden PD, Keller P, Böttger EC, Karakousis PC, Lenaerts AJ, Sacchettini JC (2017) Cell 170: 249-259
Effect of β-lactamase production and β-lactam instability on MIC testing results of Mycobacterium abscessus. Rominski A, Schultess B, Müller D, Keller P, Sander P (2017) J Antimicrob Chemother 72: 3070-3078
Lipoprotein glycosylation by protein-O-mannosyltransferase (MAB_1122c) contributes to low cell envelope permeability and antibiotic resistance in Mycobacterium abscessus. Becker K, Haldimann K, Selchow P, Reinau LM, Dal Molin M, Sander P (2017) Frontiers Microbiology 8: 2123
Intrinsic rifamycin resistance of Mycobacterium abscessus is mediated by ADP-ribosyltransferase MAB_0591. Rominski A, Roditscheff A, Selchow P, Böttger EC, Sander P (2017) J Antimicrob Chemother 72: 376-384
Elucidation of Mycobacterium abscessus aminoglycoside and capreomycin resistance by targeted deletion of three putative resistance genes. Rominski A, Selchow P, Becker K, Brülle JK, Dal Molin M, Sander P (2017) J Antimicrob Chemother 72: 2191-2200
Mycobacterium tuberculosis drug-resistance testing: challenges, recent developments and perspectives.
Schön T, Miotto P, Köser CU, Viveiros M, Böttger EC, Cambau E (2017) Clin Microbiol Infect 23: 154-160
Non-mutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase. Freihofer P, Akbergenov R, Teo Y, Juskeviciene R, Anderson DI, Böttger EC (2016) RNA 22: 1836-1843
Standard genotyping overestimates transmission of Mycobacterium tuberculosis among immigrants in a low-incidence country.
Stucki D, Ballif M, Egger M, Furrer H, Altpeter E, Battegay M, Droz S, Bruderer T, Coscolla M, Borrell S, Zürcher K, Janssens JP, Calmy A, Mazza Stalder J, Jaton K, Rieder HL, Pfyffer GE, Siegrist HH, Hoffmann M, Fehr J, Dolina M, Frei R, Schrenzel J, Böttger EC, Gagneux S, Fenner L (2016) J Clin Microbiol 54: 1862-1870
Diagnostic molecular mycobacteriology in regions with low tuberculosis endemicity: combining real-time PCR assays for detection of multiple mycobacterial pathogens with line probe assays for identification of resistance mutations. Deggim-Messmer V, Bloemberg GV, Ritter C, Voit A, Hömke R, Keller PM, Böttger EC (2016) EBioMedicine 9: 228-237
Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a TBNET/RESIST-TB consensus Statement.
Dominguez J, Böttger EC, Cirillo D, Cobelens F, Eisenach KD, Gagneux S, Hillemann D, Horsburgh R,Molina-Moya B, Niemann S, Tortoli E, Whitelaw A, Lange C (2016) Int J Tuberc Lung Dis 20: 24-42
Mycobacterium tuberculosis drug resistance testing: challenges, recent developments and perspectives.
Schön T, Miotto P, Köser CU, Viveiros M, Böttger EC, Cambau E (2016) Clin Microbiol Infect 23: 154-160
A mutation associated with clofazimine and bedaquiline cross-resistance in MDRTB following bedaquiline treatment. Somoskovi A, Bruderer V, Hömke R, Bloemberg GV, Böttger EC (2015) Eur Respir J 45: 554-557
Aminoglycoside modifying enzymes determine the innate susceptibility to aminoglycoside antibiotics in rapidly growing mycobacteria. Maurer F, Bruderer V, Castelberg C, Ritter C, Scherbakov D, Bloemberg G, Böttger E (2015) J Antimicrob Chemother 70: 1412-1419
Prolonged outbreak of Mycobacterium chimaera infection after open chest heart surgery.
Sax H, Bloemberg G, Hasse B, Sommerstein R, Kohler P, Achermann Y, Rössle M, Falk V, Kuster SP, Böttger EC, Weber R (2015) Clin Infect Dis 61: 67-75
In vitro and in vivo evaluation of synergism between anti-tubercular spectinamides and non-classical tuberculosis antibiotics.
Bruhn DF, Schermann M, Liu J, Shcherbakov D, Meibohm B, Böttger EC, Lenaerts AJ, Lee RE (2015) Sci Rep 5: 13985
Determination of MIC distribution and epidemiological cut-off values for bedaquiline and delamanid in Mycobacterium tuberculosis using MGIT 960/ TB eXiST. Keller P, Hömke R, Ritter C, Valsesia G, Bloemberg GV, Böttger EC (2015) Antimicrob Agents Chemother 59: 4352-4355
Health-care associated prosthetic heart valve, aortic vascular graft, and disseminated Mycobacterium chimaera infections subsequent to open heart surgery.
Kohler P, Kuster SP, Bloemberg GV, Schulthess B, Frank M, Tanner FC, Rössle M, Böni C, Falk V, Wilhelm MJ, Sommerstein R, Achermann Y, ten Oever J, Debast SB, Wolfhagen MJHM, Brandon Bravo Bruinsma GJ, Vos MC, Bogers A, Serr A, Beyersdorf F, Sax H, Böttger EC, Weber R, van Ingen J, Wagner D, Hasse B (2015) Eur Heart J 36: 2745-2753
Revisiting susceptibility testing in multidrug resistant tuberculosis by a standardized quantitative phenotypic assessment in a European multicenter study.
Cambau E, Viveiros M, Machado D, Raskine L, Ritter C, Tortoli E, Mattys V, Hoffner S, Richter E, Perez-del-Molino L, Cirillo D, van Soolingen D, Böttger EC (2015) J Antimicrob Chemother 70: 686-696
Acquired resistance to bedaquiline and delamanid in therapy for tuberculosis. Bloemberg GV, Keller P, Stucki D, Trauner A, Borrell S, Latshang T, Coscolla N, Rothe T, Hömke R, Ritter C, Feldmann J, Schulthess B, Gagneux S, Böttger EC (2015) N Engl J Med 373: 1986-1988
Deletion of zmp1 improves Mycobacterium bovis BCG-mediated protection in a guinea pig model of tuberculosis. Sander P, Clark S, Petrera A, Vilaplana C, Meuli M, Selchow P, Zelmer A, Mohanan D, Andreu N, Rayner E, Dal Molin M, Bancroft GJ, Johansen P, Cardona PJ, Williams A, Böttger EC (2015) Vaccine 33: 1353-1359
Evaluation of the AID TB Resistance line probe assay for rapid detection of genetic alterations associated with Mycobacterium tuberculosis drug resistance. Ritter C, Lucke K, Sirgel FA, Warren RW, van Helden PD, Böttger EC, Bloemberg GV (2014) J Clin Microbiol 52: 940-946
Transmission of multidrug-resistant tuberculosis in low-incidence setting, Switzerland, 2006 to 2012. Somoskovi A, Helbling P, Deggim V, Hömke R, Ritter C, Böttger EC (2014) Euro Surveill 19: pii=20736
Erm(41)-dependent inducible resistance to azithromycin and clarithromycin in clinical isolates of Mycobacterium abscessus. Maurer F, Castelberg C, Quiblier C, Böttger E, Somoskövi A (2014) J Antimicrob Chemother 69: 1559-1563
Postsurgical wound infections due to rapidly growing myciobacteria in Swiss medical tourists following cosmetic surgery in Latin America between 2012 and 2014. Maurer FP, Castelberg C, von Braun A, Wolfensberger A, Bloemberg GV, Böttger EC, Somoskovi A (2014) Euro Surveill 19: pii: 20905
High level resistance to isoniazid and ethionamide in multidrug resistant Mycobacterium tuberculosis of the Lisboa family is associated with inhA double mutations.
Machado D, Perdigao J, Ramos J, Couto I, Portugal I, Ritter C, Böttger EC, Viveiros M (2013) J Antimicrob Chemother 68: 1728-1732
Prosthetic valve endocarditis and bloodstream infection due to Mycobacterium chimaera.
Achermann Y, Rössle M, Hoffmann M, Deggim V, Kuster S, Zimmermann DR, Bloemberg G, Hombach M, Hasse B (2013) J Clin Microbiol 51: 1769-1773
Evaluation of Cobas TaqMan MTB for direct detection of the Mycobacterium tuberculosis complex in comparison with Cobas Amplicor MTB.
Bloemberg GV, Voit A, Ritter C, Deggim V, Böttger EC (2013) J Clin Microbiol 51: 2112-2117
Integrating the Xpert MTB/RIF assay into a diagnostic workflow for rapid detection of Mycobacterium tuberculosis in a low-prevalence area.
Deggim V, Somoskövi A, Voit A, Böttger EC, Bloemberg GV (2013) J Clin Microbiol 51: 2396-2399
HIV infection disrupts the sympatric host-pathogen relationship in human tuberculosis.
Fenner L, Egger M, Bodmer T, Furrer H, Ballif M, Battegay M, Helbling P, Fehr J, Gsponer T, Rieder HL, Zwahlen M, Hoffmann M, Bernasconi E, Cavassini M, Calmy A, Dolina M, Frei R, Janssens JP, Borrell S, Stucki D, Schrenzel J, Bötter EC, Gagneux S (2013) PLoS Genet 9: e1003318
Drug susceptibility distributions in slowly growing non-tuberculous mycobacteria using MGIT 960 TB eXiST. Hombach M, Somoskövi A, Hömke R, Ritter C, Böttger EC (2013) Int J Med Microbiol 303: 270-276
The rationale for using rifabutin in the treatment of MDR and XDR tuberculosis outbreaks.
Sirgel FA, Warren RM, Böttger EC, Klopper M, Victor TC, van Helden PD (2013) PLoS One 8: e59414
Transmission of M. abscessus in patients with cystic fibrosis.
Böttger EC (2013) Lancet 382: 503-504
Automated quantitative drug susceptibility testing of nontuberculous mycobacteria using MGIT960 / EpiCenter TBeXIST. Lucke K, Hombach M, Friedel U, Ritter C, Böttger EC (2012) J Antimicrob Chemother 67: 154-158
Acquisition of clarithromycin resistance mutations in the 23S rRNA gene of Mycobacterium abscessus in the presence of inducible erm(41) methylase.
Maurer F, Rüegger V, Ritter C, Bloemberg GV, Böttger EC (2012) J Antimicrob Chemother 67: 2606-2611
embB306 mutations as molecular indicators to predict ethambutol susceptibility in Mycobacterium tuberculosis.
Sirgel FA, Warren RM, Streicher EM, Victor TC, van Helden PD, Böttger EC (2012) Chemotherapy 58: 358-363
Mycobacterium tuberculosis transmission in a low-incidence country: role of immigration and HIV infection.
Fenner L, Gagneux S, Helbling P, Battegay M, Rieder H, Pfyffer G, Zwahlen M, Furrer H, Siegrist H, Fehr J, Dolina M, Calmy A, Stucki D, Jaton K, Janssens JP, Mazza Stalder J, Bodmer T, Ninet B, Böttger EC, Egger M (2012) J Clin Microbiol 50: 388-395
Tuberculosis in HIV-negative and HIV-infected patients in a low-incidence country: clinical characteristics and treatment outcome.
Fenner L, Gagneux S, Janssens JP, Fehr J, Cavassini M, Hoffman M, Bernasconi E, Schrenzel J, Bodmer T, Böttger EC, Helbling P, Egger M (2012) PLoS One 7: e34186
Mycobacterium tuberculosis population structure determines the outcome of genetic based second-line drug resistance testing.
Streicher E, Bergval I, Dheda K, Böttger EC, Gey van Pitius N, Bosman M, Coetzee G, Anthony R, van Helden PD, Victor TC, Warren RM (2012) Antimicrob Agents Chemother 56: 2420-2427
Effect of mutation and genetic background on drug resistance in Mycobacterium tuberculosis.
Fenner L, Egger M, Bodmer T, Altpeter E, Zwahlen M, Jaton K, Pfyffer GE, Borrell S, Dubuis O, Bruderer T, Siegrist HH, Furrer H, Calmy A, Fehr J, Stalder JM, Ninen B, Böttger EC, Gagneux S (2012) Antimicrob Agents Chemother 56: 3047-3053
gyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis.
Sirgel FA, Warren RM, Streicher EM, Victor TC, van Helden PD, Böttger EC (2012) J Antimicrob Chemother 67: 1088-1093
Mutations in the rrs A1401G gene and phenotypic resistance to amikacin and capreomycin in Mycobacterium tuberculosis.
Sirgel FA, Tait M, Warren RM, Streicher EM, Böttger EC, van Helden PD, Gey van Pittius NC, Coetzee G, Hoosain EY, Chabula-Nxiweni M, Hayes C, Victor TC, Trollip A (2012) Microb Drug Resist 18: 193-197
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Zurich Open Repository and Archive: provides open and worldwide access to the research and scholarly output of the University of Zurich, Switzerland. A focus is on qualified scientific publications.
